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Sunday, November 29, 2020 | History

1 edition of Targeting protein kinases for cancer therapy found in the catalog.

Targeting protein kinases for cancer therapy

David J. Matthews

Targeting protein kinases for cancer therapy

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  • 10 Currently reading

Published by John Wiley & Sons in Hoboken, N.J .
Written in English


Edition Notes

Includes bibliographical references and index.

StatementDavid J. Matthews, Mary E. Gerritsen
ContributionsGerritsen, Mary E.
Classifications
LC ClassificationsRC271.P76 M38 2010
The Physical Object
Paginationxiii, 702 p. :
Number of Pages702
ID Numbers
Open LibraryOL24546595M
ISBN 100470229659
ISBN 109780470229651
LC Control Number2009020804
OCLC/WorldCa338289165

Targeted cancer therapies are treatments that target specific characteristics of cancer cells, such as a protein that allows the cancer cells to grow in a rapid or abnormal way. Targeted therapies are generally less likely than chemotherapy to harm normal, healthy cells. A protein kinase is a kinase enzyme that modifies other proteins by chemically adding phosphate groups to them (phosphorylation).Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other human genome contains about protein kinase genes and they constitute . 1 Aurora-A Kinase: a Potent Oncogene and Target for Cancer Therapy Min Yan1$, Chunli Wang1$, Bin He1$, Mengying Yang1, Mengying Tong1, Zijie Long2, Bing Liu1, Fei Peng1, Lingzhi Xu1, Yan Zhang1, Dapeng Liang1, Haixin Lei1, Sen Subrata3, Keith W. Kelley4, Eric W-F Lam5, Bilian Jin1*, Quentin Liu1,2* 1. Institute of Cancer Stem Cell, Cancer Center, Dalian .


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Targeting protein kinases for cancer therapy by David J. Matthews Download PDF EPUB FB2

Complete with full-color presentations, Targeting Protein Kinases for Cancer Therapy defines the structural features of protein kinases and examines their cellular functions. Combining kinase biology with chemistry and pharmacology applications, this book enlists emerging data to drive the discovery of new cancer-fighting drugs.

An expert guide to targeting protein kinases in cancer therapy Research has shown that protein kinases can instigate the formation and spread of cancer when they transmit faulty signals inside cells.

Because of this fact, pharmaceutical scientists have targeted kinases for intensive study, and have been working to develop medicinal roadblocks to sever their Cited by: Complete with full-color presentations, Targeting Protein Kinases for Cancer Therapy defines the structural features of protein kinases and examines their cellular functions.

Combining kinase biology with chemistry and pharmacology applications, this book enlists emerging data to drive the discovery of new cancer-fighting drugs.

An expert guide to targeting protein kinases in cancer therapy Research has shown that protein kinases can instigate the formation and spread of cancer when they transmit faulty signals inside cells. Because of this fact, pharmaceutical scientists have targeted kinases for intensive study, and have been working to develop medicinal roadblocks to sever their.

An expert guide to targeting protein kinases in cancer therapy Research has shown that protein kinases can instigate the formation and spread of cancer when they transmit faulty signals inside cells. Because of this fact, pharma-ceutical scientists have targeted kinases for intensive study, and have been working to develop medicinal roadblocks to.

Targeting Protein Kinases for Cancer Therapy | David J. Matthews, Mary E. Gerritsen(auth.) | download | B–OK. Download books for free.

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Matthews, Mary E. Gerritsen #FRPV6I4OEMC. A Brief History of Protein Phosphorylation. Kinases and Cancer. A Tour of the Human Protein Kinase Superfamily. Strategic Considerations for Selecting Kinases as Drug Targets. Comparison of Kinase Inhibitor Therapeutic Strategies.

References. Protein kinases play a key role in regulating signal transduction and cell cycle pathways. Dysregulation of protein kinase activity is known to be an important factor in tumorigenesis, and this finding has accelerated the development of a number of novel anti-cancer agents that target this family of proteins [].Four groups of protein kinases are commonly by: 1.

Targeting IκappaB kinases for cancer therapy. Abstract. The inhibitory kappa B kinases (IKKs) and IKK related kinases are crucial regulators of the pro-inflammatory transcription factor, nuclear factor kappa B (NF-κB).

The dysregulation in the activities of these kinases has been reported in several cancer by: 8. Targeting protein kinases for cancer therapy.

[David J Matthews; Mary E Gerritsen] -- "Research has shown that protein kinases can instigate the formation and spread of cancer when they transmit faulty signals inside cells.

Targeting NFkB mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase Cancer Biology & Therapy, 11 (7), – [PMC free article] [Google Scholar] Aoki M, Aoki H, Ramanathan R, Hait NC, & Takabe K ().Cited by: 6.

An expert guide to targeting protein kinases in cancer therapy Research has shown that protein kinases can instigate the formation and spread of cancer when they transmit faulty signals inside cells. Because of this fact, pharmaceutical scientists have targeted kinases for intensive study, and have been working to develop medicinal roadblocks to sever their Brand: Wiley.

Title: Targeting Cell Cycle Kinases for Cancer Therapy VOLUME: 14 ISSUE: 9 Author(s):Guillermo de Carcer, Ignacio Perez de Castro and Marcos Malumbres Affiliation:Centro Nacional de Investigaciones Oncológicas (CNIO); Melchor Fernandez Almagro 3, E Madrid, Spain.

Keywords:Cell cycle, serine/threonine kinase, cancer target, cyclin-dependent kinase, aurora, PLK, NEK, BUB kinasesCited by: Other serine-threonine protein kinases such as the Aurora proteins (mostly Aurora A and B) or Polo-like kinases (PLK1) are receiving increased attention as putative cancer targets.

Other less studied mitotic kinases such TTK (MPS1), BUB and NEK proteins might also be relevant candidates as new targets. Many of these kinases are associated with human cancer initiation and progression.

The recent development of small-molecule kinase inhibitors for the treatment of diverse types of cancer has proven successful in clinical therapy. Significantly, protein kinases are the second most targeted group of drug targets, Cited by:   Protein kinases play a key role in regulating signal transduction and cell cycle pathways.

Dysregulation of protein kinase activity is known to be an important factor in tumorigenesis, and this finding has accelerated the development of a number of novel anti-cancer agents that target this family of proteins [].Four groups of protein kinases are commonly.

Complete with full-color presentations, Targeting Protein Kinases for Cancer Therapy defines the structural features of protein kinases and examines their cellular functions.

Combining kinase biology with chemistry and pharmacology applications, this book enlists emerging data to drive the discovery of new cancer-fighting : Wiley.

Find many great new & used options and get the best deals for Outlines and Highlights for Targeting Protein Kinases for Cancer Therapy by David Matthews, Isbn: by Cram Textbook Reviews Staff (, Paperback, New Edition) at the best online prices at eBay.

Free shipping for many products. Targeting protein kinases for cancer therapy. [David J Matthews; Mary E Gerritsen] -- An expert guide to targeting protein kinases in cancer therapy.

Research has shown that protein kinases can instigate the formation and spread of cancer when they transmit faulty signals inside.

Targeting protein kinases for cancer therapy. Matthews, David J. and Mary E. Gerritsen. John Wiley & Sons pages $ Hardcover RC Since their identification in the s as having an important role in oncogenesis and tumor progression, protein kinases have received increasing attention as targets for anticancer drugs.

Targeting Pim kinases for cancer treatment: Opportunities and challenges Article Literature Review (PDF Available) in Future medicinal chemistry 7(1) January with Reads. Molecular Targets in the AKT Signaling Pathway. Approaches for targeting the AKT signaling pathway include targeting receptor tyrosine kinases as well as PI3K, PDK1, AKT, and mTOR kinases.

Receptor tyrosine kinases, which are upstream of the AKT signaling cascade, are promising targets to block this by: An expert guide to targeting protein kinases in cancer therapy Research has shown that protein kinases can instigate the formation and spread of cancer when they transmit faulty signals inside cells.

Because of this fact, pharmaceutical scientists have targeted kinases for intensive study, and have been working to develop medicinal roadblocks to sever their malignant means of. Studyguide for Targeting Protein Kinases for Cancer Therapy by Matthews, David, ISBN 04/06/ Publisher: Content Technologies, Inc.

Studyguide for Targeting Protein Kinases for Cancer Therapy by Matthews, David, ISBN by Cram Textbook Reviews Never HIGHLIGHT a Book Again.

Includes all testable terms, concepts, persons Price: $   Targeting protein kinases. Affiliations. Ph.D., is a Senior Research Analyst at Life Science Insights, 5 Speen Street, Framingham,Massachusetts, USACited by: Acknowledgments.

Supported by NIH grants R01 CA, P50 CA [Dana-Farber/Harvard Center (DF/HCC) Specialized Program of Research Excellence (SPORE) in Breast Cancer], P50 CA (DF/HCC SPORE in Lung Cancer), Susan G.

Komen Post-doctoral Fellowship Award KG, and Lymphoma Research Foundation Mantle Cell Cited by: 1. The interaction between programmed cell death protein (PD-1) and its ligand (PD-L1) is one of the main pathways used by some tumors to escape the immune response. In recent years, immunotherapies based on the use of antibodies against PD-1/PD-L1 have been postulated as a great promise for cancer treatment, increasing total survival compared to standard therapy in Cited by: 2.

drugs than in cancer therapy. Kinome, the complete set of protein kinases encoded in its genome has become an attractive target for the treatment of numerous types of * Correspondence: [email protected] 6Department of Plant, Food, and Environmental Sciences, Faculty of Agriculture, Dalhousie University, Truro, NS, CanadaCited by: Colorectal cancer is the third most common malignancy in men and the second most common cancer in women.

Despite the success of screening programs and the development of adjuvant therapies, the global burden of colorectal cancer is expected to increase by 60% to more than million new cases and million deaths by In recent years, a great effort has been Cited by: 3.

Protein tyrosine kinase (PTK) deregulation contributes to growth of cancer and many other diseases. The development of small-molecule tyrosine kinase inhibitors (TKIs) that target the deregulated PTKs, such as epidermal growth factor receptor (EGFR) in non-small-cell lung cancer (NSCLC) and Bcr-ABL in chronic myeloid leukemia (CML), has revolutionized disease management.

In this book Author: Huan Ren. 12 Cyclin-Dependent Kinases (Cdk) as Targets for Cancer Therapy and Imaging Franziska Graf 1, Frank Wuest 2 and Jens Pietzsch 1 1Institute of Radiopharmacy, Helm holtz-Zentrum Dresden-Rossendorf 2Department of Oncology, University of Alberta 1Germany 2Canada 1.

Introduction Aberration in proliferation and consequently in cell cycle control is a common aspect in. Many cell cycle proteins are overexpressed or overactive in human cancers, in particular, D-type and E-type cyclins, cyclin-dependent kinases (CDK4, CDK6 and CDK2), Polo-like kinase 1 (PLK1) and Cited by:   In this review, we highlight (1) the role of the energy sensing enzyme AMP-activated protein kinase (AMPK) (9– 11) in the prevention and treatment of cancer and (2) the recent developments in this budding field that suggest AMPK as a new molecular target in the prevention and treatment of cancer by by: Protein kinases as a one of the largest mammalian gene families.

The human kinome contains eukaryotic protein kinases (ePK) genes that are sub-divided into seven families of typical and seven families of atypical protein kinases (4,5) comprising. The potential for targeting kinases in the treatment of cancer was the theme of the Keystone Symposium "Protein Kinases and Cancer: The Promise of Molecular Based Therapies" recently held in Tahoe.

It is apparent that the community pharmacist, who in the past had little or no role in the treatment of cancer, can and will play a more important role by dispensing and counseling patients about these agents. REFERENCES.

Pawson T. Regulation and targets of receptor tyrosine kinases. Eur J Cancer. ;38(suppl 5):S3-S 2. Hynes NE, Lane HA.

Our view of autophagy has emerged from unicellular yeast vesicle trafficking to mammalian physiology and human diseases.

In this chapter we summarize the major discoveries on autophagy regulation by PI3-kinases and discuss the therapeutic potentials of targeting PI3-kinases in modulating autophagy and in cancer : Zhixun Dou, Wei-Xing Zong.

A protein kinase inhibitor is a type of enzyme inhibitor that blocks the action of one or more protein n kinases are enzymes that add a phosphate (PO 4) group to a protein, and can modulate its function.

The phosphate groups are usually added to serine, threonine, or tyrosine amino acids on the protein: most kinases act on both serine and threonine, the tyrosine kinases.

Reasonably, protein kinase inhibitor drugs target and act upon signaling pathways that have gone awry in a given cancer, whereas all traditional chemotherapy drugs work on cell division and growth mostly leading to the destruction of healthy cells as the main problems in treatment of cancer : Huan Ren.

Protein phosphorylation plays key roles in many physiological processes and is often deregulated in pathological conditions. Our current understanding of how protein kinases and phosphatases orchestrate the phosphorylation changes that control cellular functions has made these enzymes potential drug targets for the treatment of many by: Cancer growth blockers.

Cancer growth blockers are also called cancer growth inhibitors. They are a type of targeted cancer drug. Growth factors. Growth factors are chemicals produced by the body that control cell growth.

There are many different types of .Targeting Src family kinases in anti-cancer therapies: turning promise into triumph Siyuan Zhang and Dihua Yu Department of Molecular and Cellular Oncology, The University of Texas M. D.

Anderson Cancer Center, Holcombe Blvd, Houston, TXUSA Src is a non-receptor tyrosine kinase that is deregulated in many types of cancer. Decades.